Neurokinin Receptor

Neurokinin Receptor Related Products (173):

By Effects:	Inhibitors (11) Agonists (21) Antagonists (93) Activator (1) Modulators (4) Controls (3)

Cat. No.	Product Name	Effect	Purity

HY-10052

Aprepitant	Inhibitor	99.82%
Aprepitant (MK-0869) is a selective and high-affinity neurokinin 1 receptor antagonist with a K_d of 86 pM.

HY-P0197

Neurokinin A		99.86%
Neurokinin A (Substance K), a peptide neurotransmitter of the tachykinin family, acts via the NK-2 receptor. Neurokinin A acts as a major mediator in human airway and gastrointestinal tissues.

HY-14407A

Fosaprepitant dimeglumine	Antagonist	98.42%
Fosaprepitant dimeglumine (MK-0517) is a proagent of Aprepitant (HY-10052). Fosaprepitant dimeglumine is a neurokinin-1 receptor antagonist, which is development for the prevention of chemotherapy-induced nausea and vomiting (CINV).

HY-16346

Netupitant	Antagonist	99.90%
Netupitant (CID-6451149) is a highly potent, selective and orally active neurokinin-1 (NK₁) receptor antagonist with a K_i of 0.95 nM for hNK₁ in CHO cells. Netupitant has antiemetic affect.

HY-109171

Elinzanetant	Antagonist	99.82%
Elinzanetant is an orally active and selective NK-1 and NK-3 receptor antagonist. Elinzanetant alleviates menopause-associated vasomotor symptoms, including hot flashes and night sweats. Elinzanetant reduces estradiol and progesterone levels. Elinzanetant can be used for the research of moderate to severe vasomotor and sleep disorders associated with menopause.

HY-P1498A

Substance P, free acid TFA	Control
Substance P, Free Acid TFA is a native substance P analog, but shows no biological activity of substance P.

HY-137462

Leucyl-phenylalanine amide
Leucyl-phenylalanine amide (L-Leucyl-L-phenylalaninamide) is a dipeptide analog. Leucyl-phenylalanine amide is a ligand of SP_1-7 with a K_i value of 10.2 nM. Leucyl-phenylalanine amide shows no binding activity to human NK-1 or NK-3 receptors.

HY-153709

Zalsenertant tetraxetan	Antagonist
Zalsenertant tetraxetan (IPN-01087) is a DOTA-conjugated antagonist of the neurohypophyseal hormone receptor subtype 1 (NTSR1). Zalsenertant tetraxetan is labeled with the radioactive isotope Lu-177 (177Lu), which can be used for molecular imaging to identify potential responders. Zalsenertant tetraxetan can be used in the radiotherapy research of solid tumors.

HY-20167A

H-Glu(OtBu)-OtBu hydrochloride		98.0%
H-Glu(OtBu)-OtBu hydrochloride is a key intermediate that can be used to synthesize prostate-specific membrane antigen (PSMA) targeting probes. H-Glu(OtBu)-OtBu hydrochloride can reduce nonspecific background binding through negatively charged linkers, improve tumor/background contrast, and can be used in prostate cancer PET/SPECT imaging studies.

HY-P0242A

Neurokinin B TFA	Agonist	99.36%
Neurokinin B TFA belongs to the tachykinin family of peptides. Neurokinin B binds a family of GPCRs-including neurokinin receptor 1 (NK1R), NK2R, and NK3R-to mediate their biological effect.

HY-117088

LM11A-31	Modulator	99.88%
LM11A-31, a non-peptide p75^NTR (neurotrophin receptor p75) modulator, is an orally active and potent proNGF (nerve growth factor) antagonist. LM11A-31 is an amino acid derivative with high blood-brain barrier permeability and blocks p75-mediated cell death. LM11A-31 reverses cholinergic neurite dystrophy in Alzheimer's disease mouse models with mid- to late-stage disease progression.

HY-135108

QWF Peptide	Antagonist	98.51%
QWF Peptide (Compound 4a) is a substance P antagonist with an IC₅₀ of 0.09 μM. QWF Peptide antagonizes the SP-induced contraction of isolated guinea pig trachea strips with an IC₅₀ of 4.7 μM.

HY-P0197A

Neurokinin A TFA		99.56%
Neurokinin A TFA (Substance K TFA), a peptide neurotransmitter of the tachykinin family, acts via the NK-2 receptor. Neurokinin A acts as a major mediator in human airway and gastrointestinal tissues.

HY-P0242

Neurokinin B	Agonist	98.48%
Neurokinin B belongs to the tachykinin family of peptides. Neurokinin B binds a family of GPCRs-including neurokinin receptor 1 (NK1R), NK2R, and NK3R-to mediate their biological effect.

HY-P0236A

Neurokinin A(4-10) TFA	Agonist	98.05%
Neurokinin A (4-10) TFA is a tachykinin NK₂ receptor agonist.

HY-117216B

L-703606 oxalate hydrate	Antagonist	99.4%
L-703606 oxalate hydrate is a potent, selective antagonist of NK1 receptor. L-703606 can be used for study of gastric acid secretion.

HY-P1186

Eledoisin Related Peptide	Activator	99.55%
Eledoisin Related Peptide is a Substance P analog that excites neurons and triggers behavioral responses. Eledoisin Related Peptide is also a tachykinin receptor ligand.

HY-P1012

[Sar9,Met(O2)11]-Substance P	Agonist	98.65%
[Sar9,Met(O2)11]-Substance P is a tachykinin NK₁ receptor selective agonist.

HY-16732

Tradipitant	Antagonist	99.95%
Tradipitant (VLY-686) is a neurokinin-1 (NK-1) antagonist.

HY-P1485A

Substance P(1-7) TFA		99.14%
Substance P(1-7) TFA is a fragment of the neuropeptide, substance P (SP). Substance P(1-7) TFA gives depressor and bradycardic effects when applied to the nucleus tractus solitarius.

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